Colts vs. Bills: Best bets, TV schedule & betting preview for NFL preseason matchup
Football is back just in time for the weekend as the Indianapolis Colts take on the Buffalo Bills tonight in Week 1 of the NFL’s preseason. Two AFC teams on different ends of the competitive spectrum will face off tonight in their first taste of preseason action.
Just for the occasion, we’ve made a handy guide for anyone looking to bet on today’s Colts vs. Bills game.
Colts vs. Bills: Week 1 Info
Date: Saturday, August 12th
Time: 1:00 PM ET
Location: Highmark Stadium, Orchard Park, NY
TV channel: NFL+
Colts vs. Bills: Preseason Odds
Money line: Indianapolis Colts (-175) | Buffalo Bills (+145)
Spread: Indianapolis Colts -3.5 (-110) | Buffalo Bills +3.5 (-110)
Game total: Over/Under 38 (-110)
Colts vs. Bills: Preseason Analysis
For Indianapolis, that all starts with rookie quarterback Anthony Richardson who will start the game for the Colts. The fourth pick in the 2023 NFL Draft, expectations are high for the quarterback out of the University of Florida. While the lights are often bright in a rookie’s first game, Richardson’s dual-threat ability figures to lessen some of that pressure.
After Richardson, the Colts have another starting-capable player who will take the field in former Eagles and Jaguars quarterback Gardner Minshew. While the mustachioed cult favorite is with a new team, reuniting with former Eagles offensive coordinator turned Colts head coach should ease that transition and give the Colts two QBs capable of producing. Which is a luxury in the preseason.
The big news for the Bills is the return of safety Damar Hamlin who suffered a cardiac arrest mid-game against the Cincinnati Bengals. The road back hasn’t been easy, but sooner than anyone could have foreseen after that terrifying moment, Hamlin is back and ready to take the field. His return will have not only his teammates ready to go, but the stadium of passionate Bills fans will rock the house today.

Colts vs. Bills: betting pick
Preseason games are notoriously unpredictable, but despite this, these two teams are in such a different place in terms of the players who will take the field today. Buffalo will not risk injury to any player who figures to play a major role, while the Colts are ready to get freaky as they’re in full “Let’s see what we got” mode.
Take the Colts -3.5 today.