MLS Matchday 21 saw San Diego FC and the Philadelphia Union stay at the top of their respective conferences. The Union faces third-place Nashville SC on Saturday, while San Diego faces 10th-place Houston Dynamo.
There are a few noteworthy clashes in the Eastern Conference this weekend, and Sunday Night Soccer will feature the Columbus Crew vs. the Seattle Sounders.
MLS Matchday 22 Schedule and Betting Guide:
*All bets courtesy of Fanduel Sportsbook

Thursday’s MLS Schedule:
NYCFC vs. Toronto FC – 7:30 pm – Yankee Stadium
Odds: Home -190, Draw +310, Away +490
Friday’s MLS Schedule:
FC Dallas vs. Minnesota United – 8:45 pm – Toyota Stadium
Odds: Home +180, Draw +250, Away +140
Colorado Rapids vs. Sporting Kansas City – 9:30 pm – DICK’S Sporting Goods Park
Odds: Home -120, Draw +290, Away +270
LA Galaxy vs. Vancouver Whitecaps – 10:30 pm – Dignity Health Sports Park
Odds: Home +140, Draw +250, Away +170
Saturday’s MLS Schedule:
Charlotte FC vs. Orlando City – 7:15 pm – Bank of America Stadium
Odds: Home +165, Draw +260, Away +145
CF Montreal vs. Inter Miami – 7:30 pm – Stade Saputo
Odds: Home +195, Draw +270, Away +115
D.C. United vs. Atlanta United – 7:30 pm – Audi Field
Odds: Home +160, Draw +240, Away +160
FC Cincinnati vs. Chicago Fire – 7:30 pm – TQL Stadium
Odds: Home -120, Draw +290, Away +270
Austin FC vs. LAFC – 8:30 pm – Q2 Stadium
Odds: Home +185, Draw +230, Away +145
Nashville SC vs. Philadelphia Union – 8:30 pm – GEODIS Park
Odds: Home -130, Draw +270, Away +310
Real Salt Lake vs. St Louis City – 9:30 pm – America First Field
Odds: Home -145, Draw +300, Away +340
San Jose Earthquakes vs. New York Red Bulls – 10:30 pm – PayPal Park
Odds: Home +100, Draw +270, Away +240
Portland Timbers vs. New England Revolution – 10:30 pm – Providence Park
Odds: Home -105, Draw +270, Away +250
San Diego FC vs. Houston Dynamo – 10:30 pm – Snapdragon Stadium
Odds: Home -145, Draw +290, Away +350
Sunday’s MLS Schedule:
Seattle Sounders vs. Columbus Crew – 5:00 pm – Lumen Field
Odds: Home -105, Draw +260, Away +260

MLS table after Matchday 21
MLS’s Eastern Conference
Philadelphia Union – 40 pts
FC Cincinnati – 39 pts
Nashville SC – 38 pts
Columbus Crew – 37 pts
Orlando City – 33 pts
Inter Miami – 29 pts
New York Red Bulls – 29 pts
Chicago Fire – 28 pts
NYCFC – 28 pts
Charlotte FC – 25 pts
New England Revolution – 24 pts
D.C. United – 18 pts
Toronto FC – 17 pts
Atlanta United – 17 pts
CF Montreal – 14 pts
MLS’s Western Conference
San Diego FC – 39 pts
Vancouver Whitecaps – 38 pts
Minnesota United – 34 pts
Portland Timbers – 30 pts
Seattle Sounders – 29 pts
San Jose Earthquakes – 27 pts
LAFC – 26 pts
Colorado Rapids – 26 pts
Austin FC – 26 pts
Houston Dynamo – 23 pts
FC Dallas – 21 pts
Sporting Kansas City – 20 pts
Real Salt Lake – 19 pts
St. Louis City – 15 pts
LA Galaxy – 9 pts

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