MLS Matchday 21 Schedule & Betting Guide: West leaders San Diego take on Dallas, Columbus hosts Philadelphia

MLS
Jun 25, 2025; Vancouver, British Columbia, CAN; Vancouver Whitecaps defender Tate Johnson (28) goes down between San Diego FC forward Milan Iloski (32) and defender Oscar Verhoeven (33) during the first half at BC Place. Mandatory Credit: Anne-Marie Sorvin-Imagn Images

San Diego FC is now the leader of the Western Conference after MLS Matchday 20. On Wednesday night, they defeated the Vancouver Whitecaps 5-3.

In the Eastern Conference, the Philadelphia Union kept a clean sheet over the Chicago Fire and is still at the top of the East and Supporters’ Shield standings. The Union will face the Columbus Crew on Sunday night at Lower.com Field with hopes of extending their 11-match unbeaten streak.

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Jun 25, 2025; Chicago, Illinois, USA; Philadelphia Union defender Jakob Glesnes (5) and Chicago Fire midfielder Brian GutiŽrrez (17) go for the ball during the second half at Soldier Field. Mandatory Credit: David Banks-Imagn Images

MLS Matchday 21 Schedule & Betting Guide:

*All bets courtesy of Fanduel Sportsbook

Saturday’s MLS Schedule

D.C United vs. Nashville SC – 7:30 pm – Audi Field
Odds: Home +240, Draw +250, Away +110

CF Montreal vs. NYCFC – 7:30 pm – Stade Saputo
Odds: Home +180, Draw +240, Away +140

New York Red Bulls vs. Minnesota United – 7:30 pm – Sports Illustrated Stadium
Odds: Home +120, Draw +230, Away +230

Orlando City vs. FC Cincinnati – 7:30 pm – Inter&Co Stadium
Odds: Home +100, Draw +260, Away +250

New England Revolution vs. Colorado Rapids – 7:30 pm – Gillette Stadium
Odds: Home -110, Draw +240, Away +130

FC Dallas vs. San Diego FC – 8:30 pm – Toyota Stadium
Odds: Home +200, Draw +260, Away +115

Chicago Fire vs. Charlotte FC – 8:30 pm – Soldier Field
Odds: Home -120, Draw +290, Away +250

Houston Dynamo vs. St. Louis – 8:30 pm – Shell Energy Stadium
Odds: Home -130, Draw +280, Away +300

Sporting Kansas City vs. Real Salt Lake – 8:30 pm – Children’s Mercy Park
Odds: Home +115, Draw +260, Away +210

Seattle Sounders vs. Austin FC – 10:30 pm – Lumen Field
Odds: Home -145, Draw +260, Away +380

San Jose Earthquakes vs. LA Galaxy – 10:30 pm – PayPal Park
Odds: Home -120, Draw +290, Away +260

Sunday’s MLS Schedule

Columbus Crew vs. Philadelphia Union – 6:00 pm – Lower.com Field
Odds: Home -125, Draw +280, Away +310

LAFC vs. Vancouver Whitecaps – 9:30 pm – BMO Stadium
Odds: Home -140, Draw +280, Away +340

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Jun 25, 2025; Chicago, Illinois, USA; Chicago Fire goalkeeper Jeffrey Gal (25) makes a save on Philadelphia Union forward Bruno Damiani (20) during the second half at Soldier Field. Mandatory Credit: David Banks-Imagn Images

MLS Standings

MLS’s Eastern Conference

Philadelphia Union – 40 pts
FC Cincinnati – 36 pts
Nashville SC – 35 pts
Columbus Crew – 34 pts
Orlando City – 33 pts
Inter Miami – 29 pts
New York Red Bulls – 28 pts
NYCFC – 28 pts
Charlotte FC – 25 pts
Chicago Fire – 25 pts
New England Revolution – 23 pts
D.C. United – 18 pts
Atlanta United – 17 pts
Toronto FC – 14 pts
CF Montreal – 11 pts

MLS’s Western Conference

San Diego FC – 36 pts
Vancouver Whitecaps – 35 pts
Minnesota United – 33 pts
Portland Timbers – 30 pts
San Jose Earthquakes – 26 pts
LAFC – 26 pts
Seattle Sounders – 26 pts
Austin FC – 26 pts
Colorado Rapids – 25 pts
FC Dallas – 21 pts
Houston Dynamo – 20 pts
Sporting Kansas City – 19 pts
Real Salt Lake – 18 pts
St. Louis City – 15 pts
LA Galaxy – 8 pts

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Image Credit: Philadelphia Union

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Featured Image Credit: Anne-Marie Sorvin-Imagn Images