It’s 49ers vs Giants to kick off week 3 of the NFL season. A primetime matchup between two NFC teams that will want to win for very different reasons is bound to give us some fireworks on Thursday night.
If you’re looking to bet on the 49ers vs Giants primetime clash, you’ve come to the right spot. We’ve not only found 5 prop bets that could give bettors some insane value, but also rounded up the best betting promos on offer to new users this week!
49ers vs Giants: Game Details

Date: Thursday, September 21st
Time: 8:15 PM ET
Location: Levi’s Stadium
TV channel: Amazon Prime
49ers vs Giants: 5 best prop bets
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San Francisco 49ers to score 3.5+ touchdowns +215
I like the Niners to win this game, but 10 points does feel like a sneaky spread, especially if the Giants have to be aggressive without Saquon Barkley. We saw them come back from an unthinkable deficit just a week ago and that can go a long way in establishing character.
While the spread is an iffy bet to place, this Niners offense is a dominant one and should comfortably put up 4 touchdowns against the G-Men. Whether New York can keep up is another question, but this prop removes the threat of a backdoor cover.
Daniel Jones OVER 214.5 passing yards -115

I’m not the biggest Daniel Jones truther in the land and I doubt he’s going to carve up a stern Niners defense the way he did Jonathan Gannon’s soft-as-pillows unit. However, there’s reason to believe that Danny Dimes will have to bring his best for 49ers vs Giants.
With Saquon Barkley likely out of the equation and a Niners offense that can score points in bunches, it’s on the shoulders of Daniel Jones to march down the field through the air if this team has any chance of keeping pace with an offense that ranks 7th in yards per game.
214 yards is beyond gettable for Daniel Jones, especially now that his receiving weapons are waking up a little and with the removed crutch of Saquon Barkley.
Parris Campbell OVER 24.5 receiving yards -115
In a prop directly correlated to an Air-Raid from Daniel Jones, Parris Campbell drew some attention against the Cards after a quiet week 1. But, even then, 4 catches for 21 yards isn’t much to write home about.
The Giants need playmakers and this is someone coming off of a 600+ yard campaign with the Colts. He’s a big-bodied receiver who can box out corners and that’s the kind of help Jones will need if the Giants are going to hang in this game.
I like Campbell to improve on his modest week 2 total and we can take advantage of a low total here as opposed to someone like Darren Waller (45) whose line is much higher.
Brock Purdy UNDER 244 passing yards -155

With Christian McCaffrey coming up against the 26th-ranked run defense through 2 weeks, something tells me that Brock Purdy won’t have to do much at all on Thursday night. If the Niners get up by 14+ points, it’s not like they’re going to be airing out. Sure, there’s a risk of some trickery that leads to massive YAC yardage, but this is the first home game of the season and one where San Fran should be able to coast to victory.
Purdy is yet to surpass the total of 220 this season. This prop gets us an extra 24 yards to play with. You can bet him to throw under 219.5 at -140, but I like this as a safer option in 49ers vs Giants.
George Kittle anytime TD +200

It’s been a slow start to the year for George Kittle, but it’s hard to imagine that cloud will last much longer. It’s not entirely the TE’s fault, with Brock Purdy leaving a lot of meat on the bone, and the veteran tight end more than happy to sit back and let the rest of the team feast.
The Giants have a lot to worry about with Deebo Samuel and Brandon Aiyuk in the mix and it’s unlikely that they’ll be able to silence a TE who went off for 83 yards in his lone game against the G-Men. Purdy will want to make sure Kittle gets his, and I think his first TD of the year is a great way to back that sentiment.
49ers vs Giants: Betting Offers
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