49ers vs Cardinals: Betting preview, best bets & predictions

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INGLEWOOD, CA – JANUARY 09: San Francisco 49ers wide receiver Deebo Samuel #19 celebrates during an NFL game between the San Francisco 49ers and the Los Angeles Rams on January 9, 2022, at SoFi Stadium in Inglewood, CA. (Photo by Jevone Moore/Icon Sportswire)

49ers vs Cardinals headlines MNF in week 11

The Arizona Cardinals and San Francisco 49ers are set to lock horns for the first of two meetings this season. Both teams are coming off significant wins, making the race for the NFC West crown even more interesting. Only three wins separate all four teams in the division, magnifying the importance of these games.

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How to watch 49ers vs Cardinals

  • When:49ers vs Cardinals, November 21st, 2022
  • Where: Estadio Azteca, Mexico
  • Kickoff: 8:15PM EST
  • How to watch: NFL Gamepass, ESPN

49ers vs Cardinals betting odds

  • Moneyline: 49ers -360 | Cardinals +295
  • Against the spread: 49ers -8 | Cardinals +8
  • Over/Under: 44 points

49ers vs Cardinals betting preview

The Arizona Cardinals played brilliantly against the Los Angeles Rams last time out, but the San Francisco 49ers tried to one-up that sentiment by beating the Los Angeles Chargers. A win for the Cardinals here would put them second in the division, while a win for the Niners could move them to the very top since the Seahawks are on a Bye.

It won’t be easy for Arizona, however. Kyler Murray is battling a hamstring injury and is questionable to play on Monday night. Backup QB, Colt McCoy, is also trying to push through an injury. Oh, and top TE Zach Ertz is also out for the season. Given that the Niners are the NFL’s top-ranked run defense, the last thing the Cards need is instability at the quarterback position, with there being every chance that this will need to be a passing-fueled win.

Speaking of the Niners, they’re enjoying quite the turnaround. The arrival of Christian McCaffrey has been an impactful one. He’s put up 170 rushing yards, 118 receiving yards, and technically accounted for 4 touchdowns. Jimmy G might not be a star, but he doesn’t have to be so long as their offense can thrive with such a versatile and explosive group of players around him.

The altitude at the stadium this weekend is going to be key. It’s over 2,000 ft higher than Mile High Stadium in Denver, which is already notorious for tiring defenses. If the Cardinals can’t get off the field against an offense that amasses 360 yards per game, they’re really going to struggle here, especially if there is a setback at quarterback.

49ers vs Cardinals betting pick

All things considered, I’m shocked the total for this game sits at 43 points. The Niners put up 17 points in both games against the Cards last year. There were 38 points in their most recent win and they’re now facing a far less potent offense due to the injury setbacks Arizona is having to work though. Sprinkle in some added altitude and the under feels like the safest play here.

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Photo by Jevone Moore/Icon Sportswire